What are Mesothelioma Causes?
The most important Mesothelioma Causes for the development of human mesothelioma is exposure to asbestos, primarily the amphiboles crocidolite and amosite.
But other risk factors such as factory workers, ship builders …, can increase the chances of developing mesothelioma.
People who end up with this disease usually have had some type of previous exposure to asbestos.
How Asbestos Causes Mesothelioma:
Mesothelioma usually develops in the mesothelium, a membrane which consists of simple squamous epithelium that forms the lining of several body cavities.
Persons with mesothelioma usually have had some type of previous exposure to asbestos.
How this works is not fully understood.
But, it is thought that asbestos fibers enter the body through the nose and mouth by inhalation or by eating / drinking and then first travel through the upper air passages, which include the trachea (windpipe), the throat, and the large bronchi (large breathing tubes of the lungs).
These airways are normally lined with mucus, and therefore most of the fibers are cleared from these upper airways by sticking to this mucus and being coughed up or swallowed.
This is on the one hand, but on the other hand, when these fibers continue to travel and reach the small airways (which is the alveoli), the body’s immune system start to surround, engulf, and remove the smaller fibers by the phagocytosis process.
The large, long, thin fibers can not be cleared as easily and may finally reach the pleura (which is the lining of the lung and the chest wall), where they may irritate and injure the cells and lead to the development of calcium containing platelike structures on the pleural lining (pleural plaques), fibrosis (scar tissue formation), or mesothelioma.
These same asbestos fibers may also damage cells in the lung itself, which can lead to asbestosis (scar tissue in the lung) and / or can lead to lung cancer.
Patients with these pleural plaques seem to be with greatest risk for developing mesothelioma.
Asbestos have also ability to travel through the lymph nodes to different parts of the body, like the pericardium (the mesothelial layer surrounding the heart).
SO these are Mesothelioma Causes
#Read also : what is mesothelioma ?